Affron saffron purple flower logo small scienceAffron®, authentic saffron extract from PharmActive BioTech Products is an innovative, unique and new-generation natural extract obtained from saffron stigmas (Crocus sativus L.) standardized to Lepticrosalides®. It is 100% safe, traceable and effective, proven through five clinical studies. Affron® is the commercial saffron extract with the largest scientific evidence behind. It is a product from Spain, 100% genetically certified, non-GMO, non-irradiated and with multiple galenic possibilities.

Affron® helps with mood, stress/anxiety/sleep, cognition, vigor and vitality, as well as relaxation, mental and physical balance, and maintaining a positive mood. It does not interfere with other natural extracts, vitamins or minerals.

Anxiety disorder is the most common mental illness in the U.S., affecting 40 million adults age 18 and older, or 18.1% of the population every year. Anxiety disorders are highly treatable, yet only 36% of those suffering receive treatment. People with an anxiety disorder are three to five times more likely to go to the doctor and six more likely to be hospitalized for psychiatric disorders than those who do not suffer from anxiety disorders. Anxiety disorders develop from a complex set of risk factors, including genetics, brain chemistry, personality, and life events.

Major depressive disorder (MDD) is one of the most commonly diagnosed diseases, with 20% of adults affected at least once in life. The symptoms of MDD include loss or excessive weight gain, insomnia, anhedonia, sadness, loss of productivity at work, thoughts of suicide, etc. The most common treatment for depression are “reuptake inhibitors” (RI) or “transporter blocker” antidepressants. These types of drugs inhibit reuptake via plasmatic transporters of a neurotransmitter from the synapse to presynaptic neurons, leading to increase the extracellular concentrations of the neurotransmitter, and therefore an increase in neurotransmission. Most of RI affect neurotransmitters, and between them: serotonin, norepinephrine (noradrenaline) and dopamine. Among the major disadvantages of this type of treatment are low success rate, relapses, possible overdose, can lead to dependence, addiction, etc. In addition, some side effects cannot be tolerated by the patients.

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and at Science Direct

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Guest: Dr. Paul Clayton
Dr. Paul Clayton graduated summa cum laude in Medical Pharmacology from Edinburgh University, prior to obtaining his PhD. A former Chair of the Forum on Food & Health (UK), and Senior Scientific Advisor to the UK government’s Committee on the Safety of Medicines, he is currently a Fellow of the Institute of Food, Brain & Behaviour (Oxford) and a visiting professor at the University of Pecs (Hungary). He works with leading doctors and clinical scientists at centers of clinical expertise in many countries, designing and supervising pre-clinical and clinical trials of pharmaco-nutritional interventions.

Dr. Clayton frequently presents at and chairs international conferences on nutrition and health, and sits on or leads the advisory boards of many companies including Uni-Vite Healthcare, VitaFoods and PharmacoNutrition AS (both in Switzerland), Biothera (USA), Gencor Pacific (Hong Kong), Biogenics (Hungary), Zinzino (Norway) and others.

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About Pharmactive

Pharmactive is a biotechnology company based in Madrid, Spain, engaged in the research, development, manufacture and marketing of natural products and active ingredients from botanicals for use in the nutraceutical and pharmaceutical industries.

From the beginning of time, people have tried to relieve pain by using all available sources, with the plant kingdom being foremost. The first confirmation is dated aprox. 3,000 B.C.E. where the calming properties of the poppy (Papaver somniferum) appeared engraved in a clay tablets. All civilizations have looked for home remedies in plants, even though many have not yet been studied or improved.

This is the focus of our company: The selection of natural products and extracts with high added value and developing analytical techniques or extraction methods to increase level of active principles with scientifically-proved therapeutical application, all with rigourous quality control.

In Pharmactive, we cover all the stages of development of a product, from its origin to its marketing throughout the world. As a result of all these processes, we have a portfolio of products which are in different levels of study.

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