“The strength of nature that awakens the skin from within.”
Discover Centextra®

Centextra™ is much more than Centella. Preclinical studies show it provides extra support to skin health in four ways: extra-resistance against oxidative stress, extra-balance for healthy inflammatory response, extra-repair to accelerate wound closure, extra-elasticity by stimulating and preserving natural collagen production.

Healthy, elastic skin can reflect the body’s internal balance. Scientific evidence shows that processes such as oxidative stress, chronic inflammation, and the gradual decline of structural proteins like collagen can accelerate visible signs of skin aging and weaken skin integrity.

Centextra® is designed to address these mechanisms from within by combining the well-known benefits of Centella asiatica with advanced Indena Phytosome® technology. At the core of Centextra® lies the power of Centella asiatica, a botanical long recognized for its role in skin physiology. Its key constituents are known to stimulate collagen synthesis, support dermal regeneration, and help reinforce the skin’s structural matrix contributing to improved elasticity and overall skin vitality.

Centextra®—Centella Indena Phytosome®

Centextra® is a next-generation botanical food-grade ingredient by Indena that combines Centella asiatica extract with Phytosome® delivery technology to support skin health, elasticity, and collagen synthesis from within.

Key Benefits & Mechanism:

  • Collagen Restoration: Its key constituents are known to stimulate collagen synthesis, support dermal regeneration, and help reinforce the skin’s structural matrix contributing to elasticity and skin vitality.
  • Enhanced Absorption: Uses Indena Phytosome® technology to overcome the poor bio-absorption typical of unformulated Centella asiatica, keeping beneficial triterpenes intact and absorbable “resulting in the advanced ingredient Centextra®.”
  • Cellular Protection: “Enhanced antioxidant action Protects against reactive oxygen species (ROS)” as noted by. It also promotes a healthy inflammatory response and speeds cell migration for repair “Encourages wound healing and accelerates skin repair.” — Nutraceutical Business Review
Firm, elastic restored: redefine skin health.

At the core of Centextra® lies the power of Centella asiatica, a botanical long recognized for its role in skin physiology. Its key constituents are known to stimulate collagen synthesis, support dermal regeneration, and help reinforce the skin’s structural matrix contributing to improved elasticity and overall skin vitality.

Healthy, elastic skin can reflect the body’s internal balance. Scientific evidence shows that processes such as oxidative stress, chronic inflammation, and the gradual decline of structural proteins like collagen can accelerate visible signs of skin aging and weaken skin integrity. Centextra® is designed to address these mechanisms from within by combining the well-known benefits of Centella asiatica with advanced Indena Phytosome® technology.

Clinical evidence of skin rejuvenation

A clinical study  demonstrated that Centextra® significantly improves key structural and functional skin parameters associated with healthy skin aging. An extensive panel of objective instrumental evaluations showed statistically significant improvements in wrinkle depth and wrinkle network, skin elasticity, firmness, and dermal density, supporting an overall enhancement of skin architecture and biomechanical performance.

These objective improvements were reflected in the overall skin appearance, which was estimated to be approximately five years younger after only three months of supplementation.

Targeting oxidative stress at the cellular level

The antioxidant activity of Centextra® was evaluated by measuring intracellular ROS production in fibroblast cells exposed to oxidative stress. The results showed that the extract significantly reduced intracellular ROS levels compared to control cells, in a dose-dependent way. Moreover, the effect of Centextra® was stronger than that observed after exposure to unformulated Centella asiatica extract at comparable concentrations.

Building the foundation for skin matrix repair potential

The in vitro scratch assay is a testing model, used to assess cell migration and wound healing by simulating the closure of a gap in a fibroblast cell monolayer. This method was successfully used to verify Centextra®’s potential for skin matrix repair. In particular, the formulated extract significantly promoted cell migration and monolayer repair, outperforming the unformulated Centella asiatica extract at comparable concentrations: after 24 hours, Centextra® achieved a wound closure rate of approximately 40%.

Safeguarding collagen for healthier skin

Collagen is a key structural protein of the dermal extracellular matrix, and plays a crucial role in maintaining the strength, elasticity, and integrity of the skin. With aging and under conditions of oxidative or inflammatory stress, collagen synthesis decreases while at the same time its degradation increases, leading to reduced firmness, loss of elasticity, and impaired skin repair capacity. The results of studies indicate that Centextra® helps support collagen homeostasis, restoring collagen levels toward physiological conditions and modulating collagenase activity.

The sustainable journey of Centextra®

The Centella asiatica used in Centextra® is responsibly sourced from two complementary supply chains in Madagascar and Sardinia, each contributing distinctive sustainability benefits while ensuring the consistent quality of the botanical raw material.

In Madagascar, Indena works through a responsible sourcing model that promotes sustainable harvesting and cultivation practices, protects biodiversity, and helps generate long-term value for local communities while minimizing the environmental and social impact of the supply chain.

In Sardinia, a dedicated agricultural hub combines sustainable cultivation with technological innovation through fully self-sufficient photovoltaic greenhouses. According to a recent life cycle assessment, this production model enables the average net CO₂ emissions associated with the cultivation cycle to become negative within five years, delivering a measurable positive environmental impact.

This integrated approach reflects Indena’s commitment to quality, innovation and sustainability, combining responsible sourcing, advanced agricultural practices and environmentally conscious manufacturing to create value for both people and the planet.

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